Short-term outcomes and safety of radiotherapy for immediate breast reconstruction with autologous flap transfer following breast-conserving surgery

Abstract Background The outcomes of immediate autologous breast reconstruction (IABR) after partial mastectomy followed by postoperative radiotherapy (RT) in terms aesthetics, treatment-related complications, and local control are unclear. In this study, we evaluated the efficacy IABR with or without RT, thus impact radiation on flap transfer. Method A retrospective cohort study involving consecutive cancer patients who underwent between July 2011 December 2017 at Shengjing Hospital was performed. Patients were divided into two groups based whether not they received RT IABR. We compared aesthetic changes size over three-dimensional coordinates various timepoints (pre-RT, 1, 6, 12 months post-RT), as well survival, recurrence rates groups. Results total, 84 enrolled, 32 group 52 non-RT group. At a median follow-up time 33.3 months, no significant difference found rate regional (3.13% vs. 3.85%, P = 1.00), recurrences occurred either pre-RT, 6 post-RT (approximately 4, 7, IABR, respectively), 77 (91.7%), 70 (83.3%), 83 (98.8%) patients, respectively, had achieved very good cosmetic outcomes, only skin color 1 month significantly differed groups, result 62.5% 96.2%, respectively ( < 0.001). No reduction observed any timepoint There differences complications including necrosis flap, infection, hematoma, seroma (all > 0.05). Additionally, grade 3 greater RT-associated adverse events during RT. Conclusion following provides aesthetically satisfactory results intolerable may safely be performed mastectomy.